分子病理学｜研究業績
原著論文（英文）
2022年～7月
Jikuya R, Murakami K, Nishiyama A, Kato I, Furuya M, Nakabayashi J, Ramilowski JA,
Hamanoue H, Maejima K, Fujita M, Mitome T, Ohtake S, Noguchi G, Kawaura S, Odaka H,
Kawahara T, Komeya M, Shinoki R, Ueno D, Ito H, Ito Y, Muraoka K, Hayashi N, Kondo K,
Nakaigawa N, Hatano K, Baba M, Suda T, Kodama T, Fujii S, Makiyama K, Yao M, Shuch
BM, Schmidt LS, Linehan WM, Nakagawa H, Tamura T, Hasumi H. Single-cell
transcriptomes underscore genetically distinct tumor characteristics and microenvironment
for hereditary kidney cancers. iScience. 2022;25:104463.
Takase H, Kato I, Ito J, Kawabata Y, Okabe T, Takeyama M, Fujii S. Giant Cell Tumor of Bone
Without Giant Cells with a Long Clinical Course: A Case Report. Int J Surg Pathol.
2022:10668969221098090.
Yamashita H, Nakajo K, Takashima K, Murano T, Kadota T, Sinmura K, Yoda Y, Ikematsu H,
Fujii S, Yano T. Recurrent metastasis risk factors in esophageal cancer post salvage
endoscopic resection for local failure following chemoradiotherapy. Dig Endosc. 2022 Apr
22. doi: 10.1111/den.14338. Online ahead of print.
Fujii S, Kotani D, Hattori M, Nishihara M, Shikanai T, Hashimoto J, Hama Y, Nishino T,
Suzuki M, Yoshidumi A, Ueno M, Komatsu Y, Masuishi T, Hara H, Esaki T, Nakamura Y,
Bando H, Yamada T, Yoshino T. Rapid screening using pathomorphological interpretation to
detect BRAFV600E mutation and microsatellite instability in colorectal cancer. Clin Cancer
Res.2022;28:2623-2632.
Chen H, Katakura S, Horita N, Namkoong H, Kato I, Hara Y, Kobayashi N, Fujii S, Kaneko T.
Immunohistochemical markers to diagnose primary squamous cell carcinoma of the lung: a
meta-analysis of diagnostic test accuracy. Ther Adv Med Oncol. 2022. 2; 14:
17588359211065152.
Adachi M, Tomioka T, Fujii S, Morishita Y, Okano W, Shinozaki T, Matsuura K, Hayashi R.
Is elective neck dissection necessary for patients with cT3-4N0 parotid gland cancer? Auris
Nasus Larynx. 2022;49:856-861.
Nomura H, Tsuji D, Ueno S, Kojima T, Fujii S, Yano T, Daiko H, Demachi K, Itoh K,
Kawasaki T. Relevance of pharmacogenetic polymorphisms with response to docetaxel,
cisplatin, and 5- fluorouracil chemotherapy in esophageal cancer. Invest New Drugs.
2022;40:420-429.
Sato D, Kadota T, Inaba A, Nishihara K, Takashima K, Nakajo K, Sawada K, Kotani D,
Fujiwara H, Yoda Y, Kojima T, Fujita T, Fujii S, Yano T. Long-term clinical outcome after
endoscopic resection of esophageal squamous cell carcinoma invading the muscularis
mucosae without lymphovascular invasion. Gastrointest Endosc. 2022;95:634-641.e3
2021年
Nakamura Y, Okamoto W, Kato T, Esaki T, Kato K, Komatsu Y, Yuki S, Masuishi T, Nishina
T, Ebi H, Sawada K, Taniguchi H, Fuse N, Nomura S, Fukui M, Matsuda S, Sakamoto Y,
Uchigata H, Kitajima K, Kuramoto N, Asakawa T, Olsen S, Odegaard JI, Sato A, Fujii S,
Ohtsu A, Yoshino T. Circulating tumor DNA-guided treatment with pertuzumab plus
trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial. Nat Med.
2021;27:1899-1903.
Tsuchida N, Kunishita Y, Uchiyama Y, Kirino Y, Enaka M, Yamaguchi Y, Taguri M, Yamanaka
S, Takase-Minegishi K, Yoshimi R, Fujii S, Nakajima H, Matsumoto N. Pathogenic UBA1
variants associated with VEXAS syndrome in Japanese patients with relapsing
polychondritis. Ann Rheum Dis. 2021:annrheumdis-2021-220089.
Ikeda M, Fujii S, Morishita Y, Hayashi R. Value of intraoperative pathological diagnosis in
decision-making regarding resection of well-differentiated retropharyngeal liposarcoma: A
case report. Int J Surg Case Rep. 2021;88:106466.
Hatanaka Y, Kuwata T, Morii E, Kanai Y, Ichikawa H, Kubo T, Hatanaka KC, Sakai K, Nishio
K, Fujii S, Okamoto W, Yoshino T, Ochiai A, Oda Y. The Japanese Society of Pathology
Practical Guidelines on the handling of pathological tissue samples for cancer genomic
medicine. Pathol Int. 2021;71:725-740.
Saji R, Nishii M, Sakai K, Miyakawa K, Yamaoka Y, Ban T, Abe T, Ohyama Y, Nakajima K,
Hiromi T, Matsumura R, Suzuki N, Taniguchi H, Otsuka T, Oi Y, Ogawa F, Uchiyama M,
Takahashi K, Iwashita M, Kimura Y, Fujii S, Furuya R, Tamura T, Ryo A, Takeuchi I.
Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of
COVID-19. PLoS One. 2021;16:e0256022.
Jogo T, Nakamura Y, Shitara K, Bando H, Yasui H, Esaki T, Terazawa T, Satoh T, Shinozaki E,
Nishina T, Sunakawa Y, Komatsu Y, Hara H, Oki E, Matsuhashi N, Ohta T, Kato T, Ohtsubo
K, Kawakami T, Okano N, Yamamoto Y, Yamada T, Tsuji A, Odegaard JI, Taniguchi H, Doi
T, Fujii S, Yoshino T. Circulating Tumor DNA Analysis Detects FGFR2 Amplification and
Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced
Gastric Cancer. Clin Cancer Res. 2021;27:5619-5627.
Sunakawa H, Yoda Y, Takeshita N, Hasegawa H, Takashima K, Kadota T, Fujita T, Akimoto T,
Fujii S, Yano T. Endoscopic resection combined with the Cryoballoon focal ablation system
in the porcine normal esophagus: a preclinical study. BMC Gastroenterol. 2021;21:234.
Shitara K, Baba E, Fujitani K, Oki E, Fujii S, Yamaguchi K. Discovery and development of
trastuzumab deruxtecan and safety management for patients with HER2-positive gastric
cancer. Gastric Cancer. 2021;24:780-789.
Lam AK, Bourke MJ, Chen R, Fiocca R, Fujishima F, Fujii S, Jansen M, Kumarasinghe P,
Langer R, Law S, Meijer SL, Muldoon C, Novelli M, Shi C, Tang L, Nagtegaal ID. Dataset
for the reporting of carcinoma of the esophagus in resection specimens: recommendations
from the International Collaboration on Cancer Reporting. Hum Pathol. 2021;114:54-65.
Katada C, Muto M, Fujii S, Yokoyama T, Yano T, Watanabe A, Iizuka T, Yoshinaga S, Tateya I,
Mitani H, Shimizu Y, Takahashi A, Kamijo T, Hanaoka N, Abe M, Shiotani A, Kano K,
Asada Y, Matsuhashi T, Umeno H, Okami K, Goda K, Hori S, Ono Y, Terai S, Nagami Y,
Takemura K, Kawada K, Ando M, Shimeno N, Arai A, Sakamoto Y, Ichinoe M, Nemoto T,
Fujita M, Watanabe H, Shimoda T, Ochiai A, Kato T, Hayashi R. Transoral surgery for
superficial head and neck cancer: National Multi-Center Survey in Japan. Cancer Med.
2021;10:3848-3861.
Kotani D, Bando H, Taniguchi H, Masuishi T, Komatsu Y, Yamaguchi K, Nakajima T, Satoh T,
Nishina T, Esaki T, Nomura S, Takahashi K, Iida S, Matsuda S, Motonaga S, Fuse N, Sato
Fujii S, Ohtsu A, Ebi H, Yoshino T. BIG BANG study (EPOC1703): multicentre, proof-of-
concept, phase II study evaluating the efficacy and safety of combination therapy with
binimetinib, encorafenib and cetuximab in patients with BRAF non-V600E mutated
metastatic colorectal cancer. ESMO Open. 2020;5:e000624.
Tsuchida N, Kunishita Y, Uchiyama Y, Kirino Y, Enaka M, Yamaguchi Y, Taguri M, Yamanaka
S, Takase-Minegishi K, Yoshimi R, Fujii S, Nakajima H, Matsumoto N. Pathogenic UBA1
variants associated with VEXAS syndrome in Japanese patients with relapsing
polychondritis. Ann Rheum Dis. 2021:annrheumdis-2021-220089.
Amemiya R, Miyoshi T, Aokage K, Suzuki J, Hoshino H, Udagawa H, Tane K, Sugano M,
Kojima M, Fujii S, Kuwata T, Ochiai A, Goto K, Ikeda N, Tsuboi M, Ishii G. Prognostic
impact of the tumor immune microenvironment in pulmonary pleomorphic carcinoma.
Lung Cancer. 2021;153:56-65.
Suzuki J, Aokage K, Neri S, Sakai T, Hashimoto H, Su Y, Yamazaki S, Nakamura H, Tane K,
Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Tsuboi M, Ishii G.
Relationship between podoplanin-expressing cancer-associated fibroblasts and the immune
microenvironment of early lung squamous cell carcinoma. Lung Cancer. 2021;153:1-10.
Tsuda H, Yoshida M, Akiyama F, Ohi Y, Kinowaki K, Kumaki N, Kondo Y, Saito A, Sasaki E,
Nishimura R, Fujii S, Homma K, Horii R, Murata Y, Itami M, Kajita S, Kato H, Kurosumi
M, Sakatani T, Shimizu S, Taniguchi K, Tamiya S, Nakamura H, Kanbayashi C, Shien T,
Iwata H. Nuclear grade and comedo necrosis of ductal carcinoma in situ as histopathological eligible criteria for the Japan Clinical Oncology Group 1505 trial: an interobserver agreement
study. Jpn J Clin Oncol. 2021;51:434-443.
Yagisawa M, Sawada K, Nakamura Y, Fujii S, Yuki S, Komatsu Y, Yoshino T, Sakamoto N,
Taniguchi H. Prognostic Value and Molecular Landscape of HER2 Low-Expressing
Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2021;20:113-120.e1.
Hasegawa H, Taniguchi H, Nakamura Y, Kato T, Fujii S, Ebi H, Shiozawa M, Yuki S, Masuishi
T, Kato K, Izawa N, Moriwaki T, Oki E, Kagawa Y, Denda T, Nishina T, Tsuji A, Hara H,
Esaki T, Nishida T, Kawakami H, Sakamoto Y, Miki I, Okamoto W, Yamazaki K, Yoshino T. FMS-like tyrosine kinase 3 (FLT3) amplification in patients with metastatic colorectal cancer.
Cancer Sci. 2021;112:314-322.
Kirishima M, Kato I, Hisaoka M, Nakatani Y, Takeda AH, Mizuno K, Tanimoto A. Solid
endobronchial tumor with EWSR1-FLI1 fusion gene – A diagnostically challenging case of
the Ewing sarcoma. Pathol Int. 71:488-490, 2021.
Nishizawa H, Baba M, Furuya M, Kato I, Kurahashi R, Honda Y, Mikami Y, Nagashima Y, Eto
M, Kamba T. t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using
fluorescence in situ hybridization. IJU Case Rep. 4:375-378, 2021.
Hongo T, Nakamura T, Miyake A, Kato I, Tateishi K, Yamanaka S, Yamamoto T. Evaluation of
tumor cell infiltration to the skull in dermatofibrosarcoma protuberans of the scalp: case
report and literature review. NMC Case Report Journal. 8: 287–293, 2021.
Katsura Y, Sasaki A, Minagawa D, Kato I, Ueda T. Endocrine mucin-producing sweat gland
carcinoma of the cheek. Dermatology Online Journal. 27: 13, 2021
2020年
Kotani D, Bando H, Taniguchi H, Masuishi T, Komatsu Y, Yamaguchi K, Nakajima T, Satoh T,
Nishina T, Esaki T, Nomura S, Takahashi K, Iida S, Matsuda S, Motonaga S, Fuse N, Sato A,
Fujii S, Ohtsu A, Ebi H, Yoshino T. BIG BANG study (EPOC1703): multicentre, proof-of-
concept, phase II study evaluating the efficacy and safety of combination therapy with
binimetinib, encorafenib and cetuximab in patients with BRAF non-V600E mutated
metastatic colorectal cancer. ESMO Open. 2020;5:e000624.
Yagisawa M, Sawada K, Nakamura Y, Fujii S, Yuki S, Komatsu Y, Yoshino T, Sakamoto N,
Taniguchi H. Prognostic Value and Molecular Landscape of HER2 Low-Expressing
Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2020:S1533-0028(20)30156-0.
Kessoku T, Kobayashi N, Yoneda M, Kasai Y, Ozaki A, Okubo N, Iwaki M, Kobayashi T,
Yoshihara T, Kurita Y, Honda Y, Tokuhisa M, Ishiki H, Hibiya T, Fujii S, Nakajima A,
Ichikawa Y. Case Reports: Transformation of End-Stage Neuroendocrine Tumors With
Uncontrollable Liver Metastasis Into a Novel or Additional Functional Phenotype.
Front Oncol. 2020;10:555963.
Kuwata T, Wakabayashi M, Hatanaka Y, Morii E, Oda Y, Taguchi K, Noguchi M, Ishikawa Y,
Nakajima T, Sekine S, Nomura S, Okamoto W, Fujii S, Yoshino T; SCRUM-Japan
GI-SCREEN Pathology Group. Impact of DNA integrity on the success rate of tissue-based
next-generation sequencing: Lessons from nationwide cancer genome screening project
SCRUM-Japan GI-SCREEN. Pathol Int. 2020;70:932-942.
Yamashita S, Hattori N, Fujii S, Yamaguchi T, Takahashi M, Hozumi Y, Kogawa T, El-Omar O,
Liu YY, Arai N, Mori A, Higashimoto H, Ushijima T, Mukai H. Multi-omics analyses identify
HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast
cancer to HER2-directed therapy. Sci Rep. 2020;10:15530.
Koike Y, Aokage K, Ikeda K, Nakai T, Tane K, Miyoshi T, Sugano M, Kojima M, Fujii S,
Kuwata T, Ochiai A, Tanaka T, Suzuki K, Tsuboi M, Ishii G. Machine learning-based
histological classification that predicts recurrence of peripheral lung squamous cell carcinoma.
Lung Cancer. 2020;147:252-258.
Nomura H, Tsuji D, Demachi K, Mochizuki N, Matsuzawa H, Yano T, Daiko H, Fujii S, Kojima
T, Itoh K, Kawasaki T. ABCB1 and ABCC2 genetic polymorphism as risk factors for
neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil
chemotherapy. Cancer Chemother Pharmacol. 2020;86:315-324.
Sato K, Mimaki S, Yamashita R, Togashi Y, Naito T, Udagawa H, Katsumata S, Nakasone S,
Miyoshi T, Tane K, Aokage K, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Goto K,
Tsuboi M, Tsuchihara K, Ishii G. Association between the mutational smoking signature and
the immune microenvironment in lung adenocarcinoma. Lung Cancer. 2020;147:12-20.
Saito Y, Hayashi R, Iida Y, Mizumachi T, Fujii T, Matsumoto F, Beppu T, Yoshida M,
Shinomiya H, Kamiyama R, Kitano M, Yokoshima K, Fujimoto Y, Hama T, Yamashita T,
Okami K, Miura K, Fujisawa T, Sano D, Kato H, Minami S, Sugasawa M, Masuda M, Ota I,
Iwae S, Kawata R, Monden N, Imai T, Asakage T, Okada M, Yoshikawa T, Tanioka K,
Kitayama M, Doi M, Fujii S, Fujii M, Oridate N, Nakamizo M, Yoshimoto S, Homma A,
Nibu KI, Yane K. Optimization of therapeutic strategy for p16-positive oropharyngeal
squamous cell carcinoma: Multi-institutional observational study based on the national Head
and Neck Cancer Registry of Japan. Cancer. 2020;126:4177-4187.
Inaba A, Hori K, Yoda Y, Ikematsu H, Takano H, Matsuzaki H, Watanabe Y, Takeshita N,
Tomioka T, Ishii G, Fujii S, Hayashi R, Yano T. Artificial intelligence system for detecting
superficial laryngopharyngeal cancer with high efficiency of deep learning. Head Neck.
2020;42:2581-2592.
Sunakawa H, Hori K, Kadota T, Shinmura K, Yoda Y, Ikematsu H, Tomioka T, Akimoto T,
Hayashi R, Fujii S, Yano T. Relationship between the microvascular patterns observed by
magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial
pharyngeal squamous cell carcinoma. Esophagus. 2021;18:111-117.
Mukai H, Yamaguchi T, Takahashi M, Hozumi Y, Fujisawa T, Ohsumi S, Akabane H,
Nishimura R, Takashima T, Park Y, Sagara Y, Toyama T, Imoto S, Mizuno T, Yamashita S,
Fujii S, Uemura Y. Ki-67 response-guided preoperative chemotherapy for HER2-positive
breast cancer: results of a randomised Phase 2 study. Br J Cancer. 2020;122:1747-1753.
Takashima K, Fujii S, Komatsuzaki R, Komatsu M, Takahashi M, Kojima T, Daiko H, Minashi
K, Chiwaki F, Muto M, Sasaki H, Yano T. CD24 and CK4 are upregulated by SIM2, and are
predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. Int J Oncol.
2020;56:835-847.
Hiyama T, Kuno H, Nagaki T, Sekiya K, Oda S, Fujii S, Hayashi R, Kobayashi T. Extra-nodal
extension in head and neck cancer: how radiologists can help staging and treatment planning.
Jpn J Radiol. 2020;38:489-506.
Miyashita T, Neri S, Hashimoto H, Akutsu A, Sugano M, Fujii S, Ochiai A, Ishii G. Fibroblasts-
dependent invasion of podoplanin-positive cancer stem cells in squamous cell carcinoma.
J Cell Physiol. 2020;235:7251-7260.
Hatogai K, Fujii S, Kitano S, Kojima T, Daiko H, Yoshino T, Ohtsu A, Takiguchi Y, Doi T,
Ochiai A. Relationship between the immune microenvironment of different locations in a
primary tumour and clinical outcomes of oesophageal squamous cell carcinoma. Br J Cancer.
2020;122:413-420.
Yukioka S, Tanaka S, Nabetani Y, Suzuki Y, Ushijima T, Fujii S, Takada H, Van Tran Q, Singh
S. Occurrence and characteristics of microplastics in surface road dust in Kusatsu (Japan),
Da Nang (Vietnam), and Kathmandu (Nepal). Environ Pollut. 2020;256:113447.
Yazawa K, Nakamura F, Masukawa D, Sato S, Hiroshima Y, Yabushita Y, Mori R, Matsuyama
R, Kato I, Taniguchi H, Goshima Y, Endo I. Low Incidence of High-Grade Pancreatic
Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic
Cancer. Transl Oncol. 2020; 13: 100746.
Hayashida K, Kawabata Y, Kato I, Suzuki M, Takeyama M, Inaba Y. G-CSF Production by
Undifferentiated Pleomorphic Sarcoma with Leukemoid Reaction Occurred in the Lower Leg:
A Case Report. JBJS Case Connect. 2020 Apr-Jun;10(2): e0624.
Mizushima T, Jiang G, Kawahara T, Li P, Han B, Inoue S, Ide H, Kato I, Jalalizadeh M, Miyagi
E, Fukuda M, Reis LO, Miyamoto H. Androgen Receptor Signaling Reduces the Efficacy of
Bacillus Calmette-Guérin Therapy for Bladder Cancer via Modulating Rab27b-induced
Exocytosis. Mol Cancer Ther. 2020;19:1930-1942.
Kunimoto H, Fukuchi Y, Murakami K, Ikeda J, Teranaka H, Kato I, Miyazaki T, Enaka M,
Mitsuhashi T, Yamazaki E, Kameyama K, Murata M, Okamoto S, Nakajima H. Establishment
of a High-risk MDS/AML Cell Line YCU-AML1 and its Xenograft Model Harboring t(3;3)
and Monosomy 7. Hemasphere. 2020;4: e469.
Sugiura K, Nakajima S, Kato I, Okubo-Sato M, Nakazawa Y, Mitsudo K, Kioi M. Hypoxia and
CD11b+ Cell Influx Are Strongly Associated With Lymph Node Metastasis of Oral Cancer.
Anticancer Res. 2020;40:6845-6852.
Hayashida K, Kawabata Y, Kato I, Kamiishi T, Matsuo K, Takeyama M, Inaba Y. Clinical and
pathological analysis of giant cell tumor of bone with denosumab treatment and local
recurrence. J Orthop Sci. 2020: S0949-2658(20)30345-6.
Morita A, Kobayashi N, Choe H, Tezuka T, Kawabata Y, Hayashida K, Higashihira S, Kato I,
Inaba Y. A rare case of osteoblastoma in the femoral head combined with cam-type
femoroacetabular impingement: A case report. SAGE Open Med Case Rep.
2020;8:2050313X20978022.
Kunimoto H, Fukuchi Y, Murakami K, Ikeda J, Teranaka H, Kato I, Miyazaki T, Enaka M,
Mitsuhashi T, Yamazaki E, Kameyama K, Murata M, Okamoto S, Nakajima H. Establishment
of a High-risk MDS/AML Cell Line YCU-AML1 and its Xenograft Model Harboring t(3;3)
and Monosomy 7. Hemasphere. 2020;4:e469
